Replicative Lifespan

Expected replicative lifespan decreases with retention probability and harmful-protein inflow but increases with the division-rate parameter. Expected replicative lifespan decreases as current biological age increases. Replicative lifespan is defined as the total number of divisions before senescence. For n = 100, m = 15, p = 0.5, and alpha = 2, expected replicative lifespan is usually about 100 to 150 divisions. The expected replicative lifespan satisfies a Markov recursion based on division probability and non-senescent transitions.