Rescue Therapy
The availability of rescue therapy appeared to prevent further average weight increases from week 24 to week 52. Other oral obesity medications were not allowed as rescue therapy. Rescue dosing began at 1 mg orally once daily and escalated…
1 sources - 5 claims
The availability of rescue therapy appeared to prevent further average weight increases from week 24 to week 52. Other oral obesity medications were not allowed as rescue therapy. Rescue dosing began at 1 mg orally once daily and escalated every four weeks to the maximum tolerated dose. Rescue therapy limited harms from weight regain but reduced the interpretability of placebo comparisons after week 24. Starting at week 24, placebo participants with at least 50% regain of SURMOUNT-5 weight loss began rescue orforglipron.