Ribavirin
The Irrua ribavirin regimen differs from the older McCormick regimen by using a higher loading dose and lower later daily dosing. In SAFARI, ribavirin followed the Irrua regimen using intravenous loading and tapering daily doses across 10…
1 sources - 4 claims
The Irrua ribavirin regimen differs from the older McCormick regimen by using a higher loading dose and lower later daily dosing. In SAFARI, ribavirin followed the Irrua regimen using intravenous loading and tapering daily doses across 10 days. Ribavirin is used as standard care for Lassa fever in Nigeria, but its efficacy and risk-benefit profile remain uncertain because older pivotal studies have critical bias risk. Ribavirin pharmacokinetics in SAFARI were best described by a three-compartment model.