Risk Prediction

The institution estimates that approximately 25–30% of medical inpatients are genuinely high-risk for VTE by the RAM, meaning even low prescribers may still be over-prescribing. Overall prescribing concordance with the RAM was 68% across more than 130,000 patient encounters. The Kidney Failure Risk Equation is a validated multinational clinical prediction model. Cleveland Clinic uses a locally derived Risk Assessment Model that has guided VTE prophylaxis decisions for over five years. Completing the RAM is mandatory for all hospital admissions, but adherence to its recommendations is not enforced. The proteomic signature enables trial enrichment by more efficiently identifying high-risk individuals for clinical research. Improved prediction accuracy enables early intervention eligibility before substantial kidney function loss.