SABR versus Surgery Evidence
The revised STARS trial reported similar 5-year overall survival for SABR and VATS lobectomy with mediastinal lymph node dissection. Major meta-analyses conflict with favorable SABR findings by reporting worse all-cause or overall survival…
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The revised STARS trial reported similar 5-year overall survival for SABR and VATS lobectomy with mediastinal lymph node dissection. Major meta-analyses conflict with favorable SABR findings by reporting worse all-cause or overall survival after SABR than after surgery or lobectomy. A small pooled analysis from STARS and ROSEL suggested SABR might be better tolerated and improve overall survival compared with surgery, but its sample size generated debate. Randomized comparisons between SABR and surgery in operable early-stage NSCLC have been difficult to complete. Prior observational studies were limited by retrospective data quality and incomplete control of selection bias.