SAFARI Trial
The study compared oral favipiravir with intravenous ribavirin, which was the Nigerian standard of care. SAFARI was an open-label, randomized, controlled phase 2 trial conducted at two Nigerian Lassa fever referral centers. The trial enrol…
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The study compared oral favipiravir with intravenous ribavirin, which was the Nigerian standard of care. SAFARI was an open-label, randomized, controlled phase 2 trial conducted at two Nigerian Lassa fever referral centers. The trial enrolled 41 participants between August 2021 and October 2022. The trial was not blinded because the study drugs differed in formulation and route of administration. SAFARI primarily aimed to characterize favipiravir pharmacokinetics and assess its safety and tolerability.