Salivary Biomarkers

The Cube Reader system for saliva analysis does not require specialized analytical infrastructure such as ELISA. Using salivary cortisol and IgA objectively assesses physiological stress responses, reducing reliance on self-report alone. Salivary cortisol is an end product of the HPA axis and a physiological stress-response indicator measurable accurately in saliva. Cortisol has a marked diurnal rhythm with high levels in the early morning and low levels at night, requiring standardized sample collection times. Salivary IgA is the predominant immunoglobulin in mucus secretions from salivary glands and may be regulated by acute and chronic stress.