Satiety Signals

Cholecystokinin is highlighted as a satiation hormone that can be increased by dietary fats, especially omega-3 fatty acids in the discussion. Persistent post-meal hunger is a physiological signaling failure, not a willpower problem. The body sends satiety signals to the brain only when cells receive adequate fat, fat-soluble nutrients, and fuel. Ghrelin is presented as a rhythmic priming signal rather than an absolute command to eat. Satiety hormones are central to the article’s physiological model of hunger and fullness. Omega-3 fatty acids are said to stimulate cholecystokinin and support fullness through the gut-brain pathway. When fat absorption, nutrient delivery, or cellular fuel uptake fails, the satiety signal never arrives and cravings persist after a full meal. People may be overfed but still hungry if they lack nutrients rather than calories. Adequate protein may be needed before full satiety hormones are activated.