Scientific Evidence

A systematic review found moderate-certainty evidence that metformin lowers HOMA-IR compared with placebo. The prior trial suggested higher-dose metformin could produce greater weight reduction and HOMA-IR insulin-sensitivity improvements. The prior dose-comparison trial included 83 women and compared 1500 mg/day with 2550 mg/day. The Quebec study's stillbirth estimate differed in direction from some prior studies, but did not show a statistically significant increased risk. The article identifies this study as the first economic evaluation of penicillin allergy testing based on RCT effectiveness data. The findings align with earlier research that generally did not find increased glioma risk from occupational RF EMF exposure. Other outcome estimates were broadly aligned with published meta-analyses and large cohort studies. A Kaiser Permanente observational study found fewer outpatient and emergency department visits among de-labelled patients. ALABAMA data did not support the large primary-care reduction assumed by the Utrecht-based model. Unsupported opinions are rejected as a basis for nutrition and supplement decisions. ALABAMA visit reductions were smaller than those in the K…