Sex Differences in Longevity
The paper describes explanations involving sex chromosomes, infection, disease, environmental factors, and social determinants as insufficient at the population level. The paper does not present a human cohort analysis linking motif burden…
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The paper describes explanations involving sex chromosomes, infection, disease, environmental factors, and social determinants as insufficient at the population level. The paper does not present a human cohort analysis linking motif burden, tissue expression, reproductive anatomy, and individual longevity. The human sex-difference interpretation is based on tissue expression and motif content rather than direct measurements of individual lifespan effects. The study argues that ovaries and endometriums contain more longevity motif activity than male testis. The paper extends its ncRNA motif interpretation to human sex differences in longevity.