Spatial Neighborhoods

Neighborhood readouts are calculated by tissue type, focal cell type, paired neighbor cell type, and distance thresholds of 20 and 40 micrometers. OpenTME computes readouts from classified cells and tissue regions, including spatial neighborhood statistics. Neighborhood metrics depend on spatial relationships between classified cells within biologically relevant local radii. For a focal cell type, OpenTME reports the tissue-contained area around those cells and the total number of neighboring cells within the threshold. For paired cell types, OpenTME reports neighbor counts, densities, ratios, and average minimum distances.