Specialized Pro-resolving Mediators

SPMs are not the fatty acids themselves but products of enzymatic conversion. Taking more fish oil may not solve inflammation when SPM conversion pathways are genetically inefficient. The article argues that whole fish may show benefits partly because it contains SPMs that conventional fish oil processing can remove. In the inflammation model, SPMs signal resolution, clear debris, and initiate tissue restoration. SPMs are downstream bioactive metabolites derived from essential fatty acids through enzyme-mediated pathways. SPM supplements deliver resolution-phase mediators directly without relying on endogenous conversion.