Spermidine

Spermidine markedly reduced TNF-alpha and IL-6 in a COVID-19 study. Diets higher in polyamines are associated with longevity, and the Mediterranean diet may owe some of its benefits to higher polyamine intake. Spermidine may enhance vaccine efficacy by improving the underlying immune environment. Spermidine fits within the category of systemic cellular health support. A full-spectrum wheat germ extract may be safer than isolated high-dose spermidine because it better resembles whole-food polyamine exposure. Spermidine was originally discovered in semen, which is the origin of its name. Spermidine was difficult to obtain in the United States for years, with early access limited to research chemicals or Japanese probiotic imports. Spermidine is unlikely to be recommended by mainstream physicians for at least 10–20 years due to the lag between emerging research and clinical adoption. Putrescine converts into spermidine, and spermidine converts into spermine, and these related polyamines are not interchangeable in terms of safety. Spermidine upregulates M2 macrophages, the anti-inflammatory macrophages responsible for pathogen clearance and dampening destructive immune responses. Sper…