Sphingomyelin Metabolism
Outer-membrane sphingomyelin dominated the sphingomyelin species pool under homeostasis. Sphingomyelin species had the highest overall noise, with variance distributed almost equally across reactions. Independent literature on impaired sph…
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Outer-membrane sphingomyelin dominated the sphingomyelin species pool under homeostasis. Sphingomyelin species had the highest overall noise, with variance distributed almost equally across reactions. Independent literature on impaired sphingomyelin metabolism in Alzheimer’s disease supported added model modifications. Sphingomyelin hydrolysis through sphingomyelinases is one modeled route for ceramide generation.