Sterigmatocystin

NAC is described as a primary supplement for sterigmatocystin because it increases catalase and superoxide dismutase while protecting against free radicals. Sterigmatocystin is structurally a precursor to aflatoxin B1 and is classified by IARC as a possible human carcinogen. Sterigmatocystin is metabolized by CYP450 enzymes in the liver and lungs into a more reactive compound. Sterigmatocystin can cause cell death, mitochondrial dysfunction, and DNA damage by overwhelming antioxidant enzymes. Sterigmatocystin is produced primarily by Aspergillus and also by several other fungal genera.