Substrate Stiffness
Cells reorganize intracellular architecture in response to environmental mechanical cues, especially substrate stiffness. Increasing substrate stiffness is proposed to drive a hierarchy of intracellular phase transitions. Substrate stiffne…
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Cells reorganize intracellular architecture in response to environmental mechanical cues, especially substrate stiffness. Increasing substrate stiffness is proposed to drive a hierarchy of intracellular phase transitions. Substrate stiffness affects the thresholds at which distinct intracellular orders become favored. Stiffer substrates permit larger traction forces by action-reaction mechanics.