Sulfation Pathway
Molybdenum at a typical clinical dose of 600 micrograms supports sulfur clearance through the kidneys and gut. When methylation is impaired or overwhelmed, the body routes estrogen and xenobiotic detoxification through the sulfation pathwa…
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Molybdenum at a typical clinical dose of 600 micrograms supports sulfur clearance through the kidneys and gut. When methylation is impaired or overwhelmed, the body routes estrogen and xenobiotic detoxification through the sulfation pathway as a backup. SULT2A1 or SULT1E1 polymorphisms make certain women genetic hypersulfators especially prone to excessive sulfation under hormonal stress. Aggressive molybdenum supplementation can worsen joint laxity in patients with hypermobility or an Ehlers-Danlos-type phenotype.