Supplements and Herbal Interventions

Enema-delivered butyrate has been specifically shown to benefit patients with distal and left-sided UC. Boswellia and turmeric are effective anti-inflammatory agents for both active UC flares and remission maintenance. Patients on long-term corticosteroid therapy should be supplemented with calcium and vitamin D to mitigate bone loss. A clinical study found four weeks of aloe vera supplementation superior to placebo for inducing remission in mild-to-moderate UC. Probiotics restore microbial balance, reduce intestinal permeability, and modulate the immune response, and are useful during flares and for maintaining remission. Correcting hypochlorhydria with HCL supplementation addresses multiple downstream dysfunctions — dysbiosis, enzyme deficiency, and nutrient malabsorption — in a single root-cause intervention.