Tangeritin

One study found that 200 mg per day of tangeritin lowered cortisol by about 20–25%. Tangeritin acts upstream in the stress response by interacting with enzymes and signaling pathways that influence how the body produces cortisol, rather than sedating the nervous system directly. Tangeritin downregulates enzymes controlling how quickly cortisol is produced, helping prevent cortisol from overshooting during stressful conditions without shutting off production completely. Tangeritin may indirectly reduce cortisol by lowering inflammation and oxidative stress, which the body often interprets as a threat that triggers increased cortisol output. Tangeritin is a flavonoid found in citrus peels, especially tangerine and orange peels, and is not commonly regarded as a stress supplement. Tangeritin is most relevant when stress is connected to inflammation, oxidative burden, or an overactive physiological threat response.