Targeted Therapy Resistance
A central resistance problem is that blocking one oncogenic signaling component can be bypassed by alternative feedback cascades. The study asks whether pathway fragility can be quantified and predicted to guide drug target combinations. D…
1 sources - 3 claims
A central resistance problem is that blocking one oncogenic signaling component can be bypassed by alternative feedback cascades. The study asks whether pathway fragility can be quantified and predicted to guide drug target combinations. Drug target combinations are framed as a way to disrupt alternative signaling cascades responsible for Ewing sarcoma growth.