TGFβ Pathway
A pan-TGFβ neutralising antibody reduced CTX and restored vertebral bone mass and architecture in the severe Crtap-/- mouse model. The response to TGFβ blockade is not universal across all genetic subtypes of osteogenesis imperfecta. Multi…
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A pan-TGFβ neutralising antibody reduced CTX and restored vertebral bone mass and architecture in the severe Crtap-/- mouse model. The response to TGFβ blockade is not universal across all genetic subtypes of osteogenesis imperfecta. Multiple model systems support targeting TGFβ signalling as a therapeutic strategy in osteogenesis imperfecta. TGFβ pathway signalling is increased in osteogenesis imperfecta for unclear reasons.