Th17/T-Regulatory Cell Imbalance
The Th17/T-reg imbalance underlying Sjogren's is shared with psoriasis and lupus. T-regulatory cells are the immune system's self-tolerance mechanism that prevent autoimmune friendly fire; their deficiency is a core defect in Sjogren's. In…
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The Th17/T-reg imbalance underlying Sjogren's is shared with psoriasis and lupus. T-regulatory cells are the immune system's self-tolerance mechanism that prevent autoimmune friendly fire; their deficiency is a core defect in Sjogren's. In Sjogren's syndrome, Th17 cells become excessive and dysregulated, losing discrimination and attacking the body's own tissues including salivary and lacrimal glands. Correcting the Th17/T-reg ratio through multiple complementary mechanisms — gut restoration, viral suppression, and targeted supplements — creates conditions for autoimmune remission.