Translation Elongation
eEF2 phosphorylation at Thr56 inactivates elongation by changing ribosome affinity. Elongation control complements stress-induced repression at initiation. CPEB2 suppresses HIF1α mRNA translation under normoxia, while hypoxia releases this…
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eEF2 phosphorylation at Thr56 inactivates elongation by changing ribosome affinity. Elongation control complements stress-induced repression at initiation. CPEB2 suppresses HIF1α mRNA translation under normoxia, while hypoxia releases this repression so HIF-1α can be synthesized. eEF2K integrates AMPK, mTORC1, and MAPK signals and can be degraded by the ubiquitin-proteasome system to allow translation recovery.