Traumatic Encephalopathy Syndrome

TES is a clinical construct and is not equivalent to confirmed CTE. TES criteria can be clinically useful but remain controversial because their symptoms are nonspecific. The 2021 NINDS consensus criteria are the central diagnostic framework for TES in the cited literature. TES-like symptoms are common outside high-risk exposure groups, which limits the specificity of symptom-based criteria. TES criteria are intended to identify a clinical syndrome during life that may correspond to underlying CTE pathology.