Urolithin A

Urolithin A extended the lifespan of C. elegans by approximately 50%. Urolithin A was identified as the active compound when it extended C. elegans lifespan while ellagitannins and ellagic acid did not. Urolithin A improved aerobic endurance and grip strength in aged rodents over six weeks. Improving mitochondrial function through urolithin A could potentially provide some beneficial effect in humans, though the magnitude is not expected to match worm data. Urolithin A is not presented as a full substitute for exercise, nutrition, fasting, or toxin avoidance. Urolithin A's effect on worm lifespan was greater than the effect typically associated with caloric restriction. The transcript describes urolithin A as an added intervention that may support pathways also affected by exercise, caloric restriction, and intermittent fasting. Urolithin A is presented as one of the more effective longevity interventions encountered in the discussed research context. Only a minority of people are described as efficiently converting dietary ellagitannins into urolithin A. Clinical trials are described as showing reduced inflammation markers and improved immune-cell measures after urolithin A suppl…