Vascular Dysfunction

In vivo evidence indicates that cell-specific expression of APOL1 high-risk variants causes hypertension and renal injury. APOL1 high-risk variant expression can cause hypertension and renal injury in vivo when expressed in specific cell types. APOL1 risk variant expression induces vascular dysfunction as part of the kidney damage pathway. APOL1 high-risk variant expression induces vascular dysfunction as a mechanism of kidney damage. Vascular dysfunction is described as part of the mechanism by which APOL1 risk variants damage kidneys. APOL1 high-risk variant expression induces both hypertension and renal injury through cell-specific mechanisms. APOL1 risk variant-driven kidney damage operates through induction of vascular dysfunction and cellular stress. Cell-specific APOL1 high-risk variant expression induces both hypertension and renal injury in vivo. The kidney damage pathway associated with APOL1 is linked to systemic vascular effects. APOL1 risk variant expression induces vascular dysfunction as a mechanism linking genetic risk to kidney injury. APOL1 risk variant expression induces vascular dysfunction and cellular stress as part of the pathway to kidney damage. The articl…