VEGF-mediated Immunosuppression
VEGF has both angiogenic and immunosuppressive effects. VEGF can impair dendritic cell maturation, reduce tumour T-cell infiltration, and increase suppressive immune cell populations. The INDUCE strategy hypothesizes that VEGF-associated i…
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VEGF has both angiogenic and immunosuppressive effects. VEGF can impair dendritic cell maturation, reduce tumour T-cell infiltration, and increase suppressive immune cell populations. The INDUCE strategy hypothesizes that VEGF-associated immunosuppressive resistance limits immune-mediated antitumour efficacy. VEGF inhibition may normalize tumour vasculature and reduce immunosuppressive features of the tumour microenvironment. High VEGF levels in liver metastases are considered capable of promoting immunosuppression through suppressive immune cells.