Vitamin D Receptor Polymorphism

People with this genetic variant may need to increase their maintenance dose to 30,000 IU, as no other intervention can override the genetic barrier. Standard vitamin D supplementation doses of 4,000–6,000 IU/day may produce little to no benefit in people with VDR polymorphism. People with VDR polymorphism may need up to 50,000 IU per day to achieve the same cellular effect as standard doses in unaffected individuals. One study using 50,000 IU of vitamin D daily for several months documented significant improvement in asthma outcomes. The vitamin D receptor polymorphism can be acquired during life, triggered by severe sustained stress, trauma, grief, or drug exposure — not only through genetic inheritance. The underlying cause of vitamin D resistance in most autoimmune patients is a genetic variant in the vitamin D receptor that reduces its sensitivity to vitamin D. Vitamin D receptor polymorphism makes the receptor structurally less able to respond to vitamin D, reducing the effect of normal doses. All or nearly all patients with autoimmune disease have an increased resistance to the effects of vitamin D. Some individuals carry genetic variants of the vitamin D receptor that redu…