WeChat-Based Intervention

PRIME-HCC tests a patient-directed alert model intended to reduce provider workload and cost. Participants in the intervention group complete weekly symptom surveys. When symptom scores exceed predefined thresholds, the platform alerts patients and provides automated evidence-based self-management advice. After each weekly survey, participants receive a personalized visual symptom report including score, concerning patterns, and trend graph. WeChat was selected because it is widely used in China and works with mobile phones and tablets. The intervention is an 18-week weekly ePRO symptom-monitoring programme delivered through a WeChat-based PRIME-HCC platform.