WNT-Driven Colorectal Cancer Stemness
ASCL2-WNT10B and ASCL2-LGR results are treated as computational confirmation of known WNT-stemness biology. Prior work connects WNT10B, WNT/R-spondin signaling, LGR5, RNF43, and ASCL2 to intestinal stem-cell maintenance and colorectal tumo…
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ASCL2-WNT10B and ASCL2-LGR results are treated as computational confirmation of known WNT-stemness biology. Prior work connects WNT10B, WNT/R-spondin signaling, LGR5, RNF43, and ASCL2 to intestinal stem-cell maintenance and colorectal tumor biology. WNT signaling helps maintain intestinal stem-cell identity and fate. The work frames candidate synergies as relevant to colorectal cancer stemness and WNT-addicted tumor biology.